This is great! I do wish there was a little more clarification about the characters and statuses, especially some examples would be useful. (For example, does a bluffing/corrupted Slayer failing to kill a good card count as a lie for the Judge? Can the Drunk be cured by the Alchemist, and does that make their bluffed ability start working?) Other than that, this is great and a very interesting puzzle!

This is such a neat system. I love how the puzzle solutions feel like a story without the rules being too contrived.

Hint 1: Vg'f vzcbffvoyr gb ernpu bar bs gur cvax xrlf, fb lbh pna yrnir gung cngu ybpxrq.

Hint 2: Fbzr bs gur qbbef pna'g or ernpurq jvgu n pregnva pbybe bs xrl.

Solution:

1. Hfr gur cher xrlf ba obgu bs gur qbbef va gur gbc ebj, nf jryy nf gur qbbe va gur obggbz ebj.
2. Bcra gur oynax oyhr qbbe va gur obggbz evtug.
3. Hfr oyhr xrlf gb haybpx rirel qbbe lbh pna ernpu jvgubhg oebja xrlf, rkprcg sbe bar guerr-xrl qbbe va gur gbc yrsg naq gur oynfg qbbe va gur obggbz evtug.
4. Hfr oebja xrlf gb haybpx gur erznvavat ybpxf va gur gbc ebj naq gur oynfg qbbe va gur obggbz evtug.
5. Haybpx gur erfg bs gur qbbef.

Isn't that already how master keys work?

You started with the purple paint already on previously, I guess they changed it to make that clearer.

I found this while browsing random jam games. I really like the interface screw abilities, and the virus themed boss fights are really clever. If you ever decide to extend this, I would play it.

I don't know how difficult this would be to implement in LOVE, but have you considered a dynamic soundtrack? Like, the music changes slightly as the difficulty increases?  The soundtrack is really cool, by the way!