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In string theory and other related theories, a brane is a physical object that generalizes the notion of a point particle to higher dimensions. For instance, a point particle can be viewed as a brane of dimension zero, while a string can be viewed as a brane of dimension one. It is also possible to consider higher-dimensional branes. In dimension p, these are called p-branes. The word brane comes from the word "membrane" which refers to a two-dimensional brane.

Branes are dynamical objects which can propagate through spacetime according to the rules of quantum mechanics. They have mass and can have other attributes such as charge. A p-brane sweeps out a (p+1)-dimensional volume in spacetime called its worldvolume. Physicists often study fields analogous to the electromagnetic field which live on the worldvolume of a brane.

In string theory, D-branes are an important class of branes that arise when one considers open strings. As an open string propagates through spacetime, its endpoints are required to lie on a D-brane. The letter "D" in D-brane refers to a certain mathematical condition on the system known as the Dirichlet boundary condition. The study of D-branes in string theory has led to important results such as the AdS/CFT correspondence, which has shed light on many problems in quantum field theory.

Branes are frequently studied from a purely mathematical point of view, and they are described as objects of certain categories, such as the derived category of coherent sheaves on a complex algebraic variety, or the Fukaya category of a symplectic manifold. The connection between the physical notion of a brane and the mathematical notion of a category has led to important mathematical insights in the fields of algebraic and symplectic geometry and representation theory given.